Biochemical mechanism of clinical resistance to rilpivirine
نویسندگان
چکیده
منابع مشابه
Biochemical mechanism of clinical resistance to rilpivirine
Background The introduction of HAART has significantly prolonged the life span of HIV-infected patients. However, the error-prone nature of HIV-1 reverse transcriptase (HIV-1 RT) results in the emergence of drug-resistant viruses and threatens the effectiveness of HAART. HIV-1 RT is a primary target of two classes of drugs: nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside ...
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BACKGROUND The prevalence of rilpivirine resistance-associated mutations (RAMs) in the USA, and their effect on phenotypic susceptibility to rilpivirine and etravirine, was evaluated in clinical samples from HIV-1-infected patients. METHODS In total, 15,991 samples submitted to Monogram Biosciences (South San Francisco, CA, USA) for routine resistance testing between January 2010 and June 201...
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Understanding the reaction form and biochemical response of wheat cultivars about the salinity stress can help to better understand the defense mechanisms and identify the indicators and biomarkers of tolerance screening for salinity stress in this strategic plant and other field crop. For this purpose, biochemical traits related to salinity tolerance of wheat cultivars were evaluated as a f...
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OBJECTIVES In the context of simplification strategies, it is essential to know the feasibility of a switch to a rilpivirine-based therapy. The aim of this study was to describe rilpivirine, tenofovir and emtricitabine resistance in HIV-1-infected patients who experienced virological failure during their previous antiretroviral treatment. PATIENTS AND METHODS The studied population included t...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2012
ISSN: 1471-2334
DOI: 10.1186/1471-2334-12-s1-p94